DRB1 Gene Patterns of Two Iranian Sheep Breeds

Authors

  • M. Nikmard Department of Animal Science, Faculty of Agriculture, University of Zanjan, Zanjan, Iran
  • M. Sohrabi Department of Animal Science, Faculty of Agriculture, University of Zanjan, Zanjan, Iran
  • M.P. Eskandari Nasab Department of Animal Science, Faculty of Agriculture, University of Zanjan, Zanjan, Iran
  • R. Osfoori Agricultural Biotechnology Research Institution of Iran, Karaj, Iran
  • V. Molaee Department of Animal Science, Faculty of Agriculture, University of Zanjan, Zanjan, Iran
Abstract:

Genetic improvement programs may improve disease resistance in animal production. The best-characterized genetic control of disease resistance and immune response in animals is the one associated with the Major Histocompatibility Complex (MHC). The ovine lymphocyte antigenof DRB1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to CD4 + T helper cells. DRB1 is the most polymorphic gene in sheep and it has been extensively evaluated as a candidate marker for associations with various ovine diseases and immunological traits. Aim of this study was to analyze exon 2 Ovar-DRB1 gene polymorphism in two Iranian native sheep breeds (Afshari and Zel). PCR products were characterized by the restriction fragment length polymorphism (RFLP) technique using two restriction enzymes, RsaI and HaeIII. In the studied groups of Afshari Sheep and Zel Sheep of Iran we were able to identify 9 restriction patterns (a, b, c, d, e, f, g, h and i) for the fragments of exon 2 Ovar-DRB1 gene with RsaI enzymatic digestion and 5 patterns (a, b, c, d and e) with HaeIII enzyme, including one previously unrecognized allele (c).Our results indicate that exon 2 of the Ovar-DRB1 gene is highly polymorphic in both breeds.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

drb1 gene patterns of two iranian sheep breeds

genetic improvement programs may improve disease resistance in animal production. the best-characterized genetic control of disease resistance and immune response in animals is the one associated with the major histocompatibility complex (mhc). the ovine lymphocyte antigenof drb1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

full text

Exon 2 Ovar-DRB1 gene polymorphism in the Iranian Sangsari sheep

The major histocompatibility complex (MHC) plays a central role in the control of disease resistance and immune response. Extensive genetic diversity in MHC genes provides a valuable source for genetic improvement, via selection, in many domestic animals. Exon 2 of the class II MHC, termed Ovar-DRB1 in domestic sheep (Ovis aries), has been suggested as important disease resistance and immune re...

full text

Polymorphisms of the Ovine Leptin Gene and its Association with Growth and Carcass Traits in Three Iranian Sheep Breeds

Leptin (LEP), the expression product of the obese gene produced primarily in the adipose tissue, is related to feed intake, growth and lipid metabolism. The aim of this study was to study the possible association between polymorphism of the LEP gene with growth and carcass traits among three Iranian sheep breeds of the Shal, Zandi and Zel varieties. A total of 180 purebred animals of the Shal, ...

full text

conjugated linoleic acids, amino acid profile and other characteristics of meat produced under identical condition from two iranian fat tailed breeds of lamb

گوشت قرمز یکی از مهم ترین فرآورده های دامی در تأمین پروتئین و انرژی می باشد که در حمل ویتامین های محلول در چربی نیز حائز اهمیت می باشد. انسان مانند سایر مهره داران اسید های چرب ضروری (لینولئیک و آلفا لینولنیک) مورد نیاز خود از طریق غذا تأمین می نماید. اسید های چرب ضروی پیش ساز اسید های چرب غیر اشباع با چند پیوند دوگانه هستند. اسید لینولنیک پیش ساز اسیدهای چرب امگا 3 و اسید لینولئیک نیز پیش ساز ...

Sheep breeds in Rajasthanx

b) Numbers. The total sheep population in the Chokla distribution area was 0.53 m according to the 1972 census and 0.511 m according to the 1977 census, thus showing a slight decline. Of these, adult males and adult females were 0.049 and 0.352 m respectively. Chokla is perhaps the finest carpet-wool breed, although most Chokla wool is now being diverted to the worsted sector because of the dea...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 3  issue 3

pages  561- 565

publication date 2013-09-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023